Gastric-duodenal ulcer is a common gastrointestinal disease, the outcome of an imbalance between ulcerative factors (hydrochloric acid solution, pepsin, helicobacter pylori) and protective factors in the liner of the intestinal, digestive, gastrointestinal mucosa. Thick (mucus, bicarbonate, prostaglandin).
H. spirochetes play an important role in the risk of ulceration: about 95% of duodenal ulcers and 70-80% of gastric ulcers have this bacterium. They cause long-term gastritis and increase acidity secretion. Elimination of L. pylori results in fast onset of ulceration and a marked lowering of occurance rates.
The goal of treating peptic ulcers is:
- Anti-ulcer factors:
. Antacids: Acidic acid in the stomach (magnesium hydroxide, light weight aluminum hydroxide... )
. Drugs that reduce acid secretion and pepsin: antihistamines H 2 and proton pump blockers.
Dangerous gastric acid release of HCl into the stomach is caused by histamine, acetylcholine and gastrin via They would + / K & - ATPase (proton pump).
Prostaglandins play an important role in back unsafe effects of mechanisms: PGE 2 adenylcyclase inhibitors reduce AMPv, antagonize histamine and inhibit gastrin release. PGI2 stimulates epithelial cells of the intestinal, digestive, gastrointestinal mucosa, which boosts the release of mucus, bicarbonate to protect the mucosa. Nonsteroidal anti-inflammatory drugs inhibit prostaglandin synthesis, can cause ulcer and gastrointestinal bleeding.
Antacids are drugs that neutralize chemical p in the gastric drink, raising the pH of the stomach to practically 4, facilitating the reconstruction of mucosa. As the pH of the abdomen increases, pepsin's activity reduces (pepsin is inactivated in pH greater than 4).
Antacids have a quick but short-acting antidiarrheal agent, which is merely a symptom-free, pain-killer.
If the abdomen is empty, the antacids escape from the abdomen after 30 minutes, when the food is about 2 hours.
One of the most commonly used antacids are aluminum and magnesium preparations, which may have an antacid effect in position, are almost ineffective in the blood and therefore have little effect on the body. Antacids containing magnesium (mg) are laxative, whereas light weight aluminum containing drugs can cause constipation. Therefore, antacid arrangements containing both magnesium and aluminum salts may reduce the undesirable effects on the intestines of these two drugs. If normal kidney function, there is very little likelihood of magnesium and aluminum build up.
Natribicarbonate has a strong neutralizing effect on acid, but it is almost no longer used as an antacid, as it is absorbed into the bloodstream, creating undesirable results on the body and acid secretion. Acid after stopping the drug).
The best antacid is after meals 1-3 hours and before going to pickup bed, 3-4 times (or more) in a day. Chemical compositions are more effective than solids but have shorter shelf life.
By simply increasing the pH of the stomach, acidic drugs interfere with the compression of several other drugs, should take these drugs away from antacids no less than 2 hours.
Several antacid combo medications with simeticon (anti-foaming agent) to relieve or minimize the symptoms of hiccup.
Magnesium (mg) hydroxide - Mg (OH) 2
Effects and components
In the stomach, magnesium (mg) hydroxide reacts quickly with hydrochloric acid:
Mg (OH) 2 + 2HCl - MgCl2 + 2H2O
In to the small intestine, Mg2 + acts on the phosphate (PO43-) and carbonate (CO32-) ions to form very little soluble or insoluble salts, thus staying away from base absorption, avoiding bloodstream base even after long use.
Other salts of magnesium may be used, such as magnesium carbonate, magnesium trisilicate.
Improved acid secretion (pain, belly pain, indigestion, heartburn, heartburn) in people with ulcer or without gastric or duodenal ulcer.
- Gastroesophageal reflux.
Cigarette essential, severe renal impairment, small kids (especially dehydration and renal failure).
Vomiting, vomiting, belly pain, diarrhea, hyperkalaemia (in patients with renal failure or high doses, prolonged).
Antacid drugs with the same antacid: tetracycline, digoxin, indomethacin, iron salts, isoniazid, benzodiazepine, ranitid
Increased medication effects by reducing the excretion of the same antacid drug: amphetamine, quinidine.
Adults: Every dose 300-600 mg, up to 1g, 3-4 days and nights. Chew medicine before ingesting.
Aluminum hydroxide - 's (OH) 3
Effects and mechanisms
In the abdomen, aluminum hydroxide reacts with hydrochloric acid:
Approach (OH) 3 + 3HCl - AlCl 3 & 3H 2 O
Lightweight aluminum hydroxide has a weakened acid neutralizing effect so they must do not cause acidosis reaction.
Found in the intestine, aluminum combines with food phosphate, absurde aluminum phosphate, almost unabsorbed, excreted in faeces, would not cause basal blood. Since phosphate is eliminated, the entire body
Must mobilize phosphate from the bones out, easy to cause osteoporosis. Subsequently, it is important to eat high degrees of phosphate and protein.
Just like magnesium hydroxide. Hypercholesterolemia (rarely used
Im Anton and.
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